Endocrine Abstracts

A 4.9-year-old girl presented with symptoms suggestive of early puberty and rapid growth. Her medical history revealed that she had been a tall child since infancy. Family history was notable for Lynch syndrome in her father and paternal grandmother. Upon examination, the patient was pre-pubertal but had a height of 124 cm (SDS 3.5) and a height velocity of 15 cm/year. Further investigations revealed elevated levels of IGF-1, IGFBP3, and failed GH suppression on an OGTT, indic...

Background: Childhood tumours of the hypothalamic pituitary axis (HPATs) are very rare and hence any single centre experience is limited. Without evidence-based guidance, treatment is individualised on a case basis. Survival rates are high, but at the expense of significant morbidity. Centralised care or wider multi-professional consultation may improve neuroendocrine and visual outcomes.Objective and hypotheses: 1. To facilitate multi-professional dial...